Probably a real dumb question but ....

DionR said

Would E85 work? I know a dedicated E85 build shoots for some pretty high compression ratios but no idea if 13:1 + boost is too high.

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In a very light race car with deep gears and an excellent intercooler you might be able to make it work on low boost. But where’s the fun in that? At that compression you need better fuel.