400/426 Stroker. Ever heard of one?

Offsetting the rod brgs that much might leave precious little metal around the oil holes, an area under a lot of load...& flexing.

If you are going to build a high rpm engine utilising a large rod/stroke ratio, then the engine will need a high flowing induction & exh system to make use of that r/s ratio.

Personally, I would use shorter rods, which is what I did [ 383 rods & 440 crank ].