Looking for some Hemi help...

I have to disagree. I have put camsin countless lx's with the mds still active, and they have not had any valve float.

but to answer martins question about the carb setup yes you will need to change them.
Yes if the mds is still active they will hold pressure. I have installed many many LX cams as well I just know that the first thing to go if your not usding the mds is the lifters.