Opinion: Small motors more or less consistent than big motors?

I'll comment from a Stock Eliminator viewpoint, as Locomotion did.
A good friend, who has sinced passed away, ran a 273 2bbl in U/SA. Weather changes were it's bugaboo. But, as Locomotion mentioned, he learned it's quirks, and well enough to be number 5 in national points one year. He also ran a few 440 Six Pack cars in C and D/SA. One of which was 1/2 mine. :-) They were much more predictable, less affected by air changes. Our car would run within a couple hundreths on a given afternoon with fairly stable air.
I've heard that an air/fuel ratio that's a tad on the rich side, may be a touch slower, but will be more consistent.
I wonder how the computer/fuel injection cars fare? Meaning, do they compensate automatically, or is their computer modified so that dial changes are needed?