What is a good combo for turning high rpm?

ou812 said
I just feel that the extra stroke over the 318 crank is worth it. You will need a solid roller cam and lifters to run that rpm for sure. Once you get a good combo to spin that high and make power up there, you'll have alot more than 400HP. I would figure closer to 550HP and maybe more.

So you could put W2's on the 318 to keep HP down...I guess?
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From everything I'm told about getting more rpm out of an engine I always hear not to increase the stroke because the longer the stroke the faster the relative piston speed which is harder on parts. Is this not true?