Holley 500 CFM 2 Barrel #0-4412S on a Slant 6

That's interesting, and it would seem to tell us that at full throttle, even with what is effectively, a smalller carb (when rated at the parameters that Holley applies to 2bbs vs. 4 bbls) it still has sufficient flow to make as much power as the rest of the engine can support. The better torque, at lower rpms, exhibited by the 4-barrel carb, is evidence of better fuel atomization and distribution, even though the carb has superior total flow capability.

Which is why a Thermoquad is such a great carburetor.