slant six MPG build e 85
What you want is torque. Running up into the fat part of the torque curve for acceleration, then backing off gives the best fuel economy.
Cubic inches make torque. Volume makes torque.
Use a 225, and back the compression down to a max of 9:1. Then stuff the heck out of it with a turbo. 12 to 15 psi as a daily driver is ok if you are going to run E85.
When you get into turbos, you need to start to think in mass air flow. Pounds of air per minute. If you can get to the point of stuffing 45 pounds of air in that engine per minute, along with 4.5 pounds of fuel - you will have as much power as you can stand.
I second the auto trans idea, I always had good results with a turbo that was loaded that way.
Good luck with your project.
B.