Well, I guess "freeway friendly" is a matter of personal taste... You drive 62 mph around here on the Interstate, and these Arkansas hillbillies will run over you in their LS-inspired farm trucks... LOL!!!!
With a 28"-tall tire, and 3.91 gears, 75 mph works out to 3,523 RPM, (plus converter slip)not exactly a relaxed crank speed for a motor with a 4.125" stroke.
Not really what ~I'd~ call "freeway friendly."
Your planned 4.88's will require 4,397 RPM at the same (75 mph)freeway speed... plus converter slip.