Cast, Hyper, Forged? Timing?

Hey all, piston choice question. I've been all over the site and this is what I've come up with regarding forced induction and pistons. 1st choice is forged. Second choice seems to be cast or hyper depending on the thread. Guys are running both cast and hyper with turbos and superchargers and getting results. My question is this: I have some free cast pistons which will give me a static comp ratio around 8.5:1. I will be using water/meth injection and higher octane fuel with megasquirt and a wideband O2. How likely is it that I'll blow holes in pistons? Do you hear detonation and its to late or can you get off the loud pedal asap and be ok? I planned on starting with a really conservative tune say 23 deg total and building it up carefully on a dyno until I start losing power and then taking that last degree out? Appreciate any advice.