I know, you think if it was so easy the factories would had stroke the engines years ago and skip building big block engines. What did the factories do, they built the engines for rpm's with forged cranks and pistons. Ford had the 302, Chevy had the 327 and Mopar had the 340, all built to handle rpm's.
U need good heads, ported for sure. Maybe the RHS? forget the small port heads the engine needs to breath.
I would try for 10 to 1 compression and a solid cam for rpm's Comp Magnum 280 has been around for ages and works well. With a high stall converter it drive around town just fine.