Self Employed???

My present job of 13 years is really taking a mental and physical toll on me.. Although it is a very well paying job with good benefits I am really wanting to take a leap of faith and start my own business( have something in mind).Would like to hear from some people who have done the same.. Would like to hear from people who have succeeded and failed.. Any input is appreciated. Only rule I have is NO political crap from either side... Thanks..