I don't know as much as some others but my OOTB Eddies on my 318 feel just fine down low and I only have around 9.5:1 CR.....if I had another point I'm sure it would be even better.
Just think that if you had a smaller runner head that was built properly for your engine, that the power that the engine would make. You wouldn't need NOS to run 11.80's you would be running faster with out it and on pump gas. And you really need to be up around 11.5:1 compression ratio to make the aluminum heads work properly, due to heat dissapation. Also the larger the runner the more fuel is consumed, something thats not wanted for street use.