To spray or not to spray

is it safe to run a good mechanical pump with a 100shot or 125shot and hyper pistons?

This is a case of: it depends. I don't know about Hyper pistons, I have never run them. Years ago, on my first nitrous experiance, I put a 125 HP plate on a 74 Dart 318. Totally stock except for a LD4b Manifold and a Holley 4bbl from a 440 engine. Installed a Carter high volumm (What they called a NASCAR pump). This was my wifes street car and sometime drag car. In 4 years never had a problem. The car/engine had over 100,000 miles on it when installed, over 130,000, when I removed the nitrous and gave the car to my neice. Do a fuel flow test to verify the fuel system is up to snuff.
PS: car ran high 13's with a 2.93 pegleg. stock exhaust manifolds and open pipes.