Sure it will run. I am at 11+ with iron heads. I can rumble through town if I keep the load off.
But it's really kind of pointless. You will have all this power that you can't use. Hell, a Geo Metro would probably beat you in a drag race, at least it won't be in chronic detonation when hammering on it, like you would be.
I ran 11:1 on pump gas and iron heads, with 4.10s, and, yeah, I had to back off the timing (a lot) to keep the detonation at a point where I didn't cringe (too much) when I hit it.
But the only drag race I ever lost was a half-length to a built 350 with a 150 shot of nitrous (and, in his words, "I was on the button hard"):D