What real difference does the lsa on a cam make?

I'm just looking for a nice street cam that's better than the stock specs. I'm probably having the heads milled a bit to bump the comp up. Also a while ago, a friend of mine had a cam in his 302 mustang that worked very well with what he had, he specs were 222/222 duration at .050 and .498/498 lift with a 110lsa, but it was a hydr flat tappet. I wanted to match pretty close because I believe that it would be a nice bump up from stock (434 lift, 180ish duration at .050, and 114?lsa). For a mild 5.2 with a 25-2800 stall converter, I think it should be pretty stout.