While the piston speed will be higher and a little more rod angularity, as long as most of your 4 day a week driving is just normal commuting and not revving the wee out of it, i don't see much of a issue. Considering you need rods & pistons anyway, might as well just buy a nice cast crank 416 kit (Scat seems to be popular?) and enjoy the cubes. Afterall you wont have to gear the crap out of it to get it to run real strong.
http://www.rpmmachine.com/340-416-chrysler-stroker.shtml