I did a bunch of dyno testing (chassis dyno since the engine was in the car) for a magazine article a few years ago where we looked at single pattern vs. dual pattern. It was a big block Mopar so we started with the classic Mopar Performance .528 solid cam which is an old school single pattern cam. Then we worked with a cam engineer at a major cam company. We tried a bunch of different cams with the latest aggressive lobe designs, split patterns, etc.
Bottom line was that nothing we tried worked better than the old MP .528 cam single pattern grind. I'm not saying that we would not have found a better cam if we had spent more time on it, but I spent 6 weeks testing and I was too worn out to look anymore!