Pump gas compression

An encyclopedia could be written on this subject. This is my latest project. 10:1 360 in a 3350# A body with 4.56 gears, 5000 stall 8" verter, 252* @ .050 cam, iron heads, good cooling system, properly tuned. Working great. Now put that same motor in a 4000# sled with a stock converter, hiway gears, shorter duration cam, timing and carb all outa wack. That thing will kill itself. Highest acceptable compression is a relative thing, but some guys just make blanket statements without taking all the variables into account.