It will work pretty well, but you're going to have to creep up on the spray. That's a lot of cylinder pressure to be putting through your head gaskets and bolts/studs.
I'm running 11:1 in my 390, but I kept the LSA down to 114 degrees to bleed off some pressure. It is still really healthy off the bottle, but when I spray that sumbitch, it REALLY wakes up.