tune up advice

Hi just got my 451 in and running,want some tuning advice,the cam is hydraulic comp 285hl,...241,247 @ 50,with ported stealths,with an msd ready to run,have a light blue and light silver springs in dizzy(2nd quickest setup there is)engine is 10.25 to 1 compression with full tti headers and 3 inch system,i run it on 98 premium and octane booster............thoughts on initial and total timing,at the moment i have the 21 degree advance stop bushing in.....thanks in advance matt!!!!!!!!!!!!!