The e-curve is supposed to be a bit of a beastly unit. It's good to hear it's working for you.
It's not unusual for old harmonic balancers to become flexible where the rubber coupling joins the inside from the outside and this can cause the timing marks to become unreliable.
But if your balancer is in good condition and relatively new it probably shouldn't be a problem.
If you're setting the advance by checking for pinging, you have to give yourself head room for bad fuel/bad weather/sustained low RPM at WOT.