5.7L hemi #6 Cylinder misfire

I would not disconnect the MDS. First of all make sure you are using the right WEIGHT of oil.
If not change it first.

The MDS system has MDS solenoids that are located under the intake manifold. They have a high failure rate. If you have verified coil and injector are not the problem, this is prob what the is causing the problem. You do not have to remove the heads! Intake only.

While there check the MDS lifter, they also have been know to stick in the collapsed position

The lifters cannot turn as they are held in with a plastic retainer.

also check the valve spring and see if it is broken. If it is remember to ID the rocker arms as the are different between intake and exhaust. The intake usually has a I stamped on it.

Take care also that the push rods are also different lengths between the intake and exhaust.

In the lifter pic the pins are pushed in for MDS operation allowing the lifer to collapse. They will be stuck in

The yellow in the MDS pic is showing oil flow for MDS operation

Lastly the heads to have to come off if you notice a lifter problem