I had a wheel bearing go out on one. It was in a '72 duster 198 slant 6 3 spd standard on the floor.
I never abused it to cause this, i just swapped the axle and all out of the left side from another one i had laying around in a parts car and drove it for another 10,000 miles before i sold the car.
All the other ones i had didn't give me any problems at all, but i never abused them either.
One was in a '69 Coronet 4 door with a 318 auto that i drove for years.......
