Stroking theory question

Be it LA, Mag, or gen 3 Hemi can be applied to either and/or all 3. So the question is what kind of stroke (biggest) can they handle, which I already know there is a 4.250 stroke crank out there but what about a 4.5 or 4.75 hell even a 5.00 stroke in them? Is there massive interference with the block at that stroke point? Just no body has thought of/try that big or what? What do you guys/gals think about a small block with a 5" stroker crank in it. Just thinking out loud here.:burnout:

P.S. For hell of it what kind of output would it make with a 5" stroke, 10 to 1 (or 11 to 1 if you prefer) with a .650/.650 solid roller on 110 say 265/265 @50 duration (by all means pick a better cam those number were picked out of a hat)?