273 Stroker, 4.00" Crank

So, this topic may have been be beating a dead horse, but I notice some crankshaft manufacturers, like Eagle for example, list a 273 as compatible with a 4.00" crank. However, I don't seem many people ever mentioning or stroking a 273. Is there some extra machining or clearancing to stroke a 273? Are there interferences in the rotating assembly or problems with flow? I'm just asking for curiosities sake.