$7000 paint job
The problem with doing anything other than a high end paint job is the difference of what is acceptable for the painter and what is acceptable for the customer. 2 different things. The first thing most say is it doesn't need to be perfect.
Isocyanates are still present in the activated materials and you can't smell them. low VOC applies to the solvents mostly. It's really difficult to have 100% protection as isocyanates can be absorbed directly through the skin and eyes. If your mixing it on the bench your getting exposure. For the DIY guys, read the MSDS sheets of what your being exposed to. Those half masks don't protect you. It's hard to put a value on the exposure.