first start break in

I'm thinking about taking the thermostat out for the first start to keep it as cool as possible and not have a burp problem. I know some people put holes in the thermostat, but I was thinking of pulling it for that 2000+ rpm break in for 30 minutes. I'll be trying some new electric fans at the same time so I don't want any current problems on trying to run this motor that hard for that long for the first time. What do you think? Thank you
410 stroker with solid cam & lifters

Drill the stat, put it back in and be done with it for good.
You will never have that "burp" problem again.

You can fill it with coolant, and then as soon as it's running you can top it off because the 1/8 hole in the stat will let the bubbles from the block out right away instead of getting hot spots till it opens.

Now if you want to try and keep it cooler than actual running temp during initial break in, that's a different story.
Leaving the stat out could very well cause it to overheat and have to be shut down before your break in time is done. (like already mentioned)