highway cruising with 4.10 gears
I've done it, 80 miles one way to the track, race it and drive home through NYC traffic. It's not a huge deal but just know it's not like driving a 'regular' car. I am around 3,200 rpm at 55 mph. To compound things, I have a manual valve body in my Duster, I need to pay attention to shifting more than normal, particularly in traffic.
I also concur with the guy who mentioned the noise factor. The continuous drone of 40 series Flowmasters at 3K can get annoying. But hey, it's a hot rod, it's supposed to be loud.