For less than $1500, you can have a complete Hotwire Auto "Hotrod" wiring harness, a rebuilt ECU for a manual transmission car without the security function and a handheld programmer loaded with a couple of custom tunes designed for your combination. If you add a wideband, the tunes will be dialed in to optimize your A/F ratio's in real time. It's as plug-and-play as it gets and comes complete with factory reliability.
I have this set-up on my 408" Magnum, and I love it. All the sensors are factory, but I did spring for bigger injectors. My cam choice did result in lower vacuum, but the reflash took care of that issue.