FiTech EFI system

I got the 1200 hp unit because I am running e85 on a 416 sb, that Mike at MRL built. It dynoed at 650 but the system was an accel and the engine never did right run with the Accel.
My fuel system was already capable of supporting it.
So running the E85 did you have to increase your engines CID by 25% to 30% in the initial setup process? Example if you've got a 416 sb did you have to program the initial setup as a 520 CID or a 541 CID to trick the Throttle body to supply the right amount of E85 fuel?