4.250 crank factory 340 block

I got a 71 340 block that's bored .040 over, the machine shop did a sonic test and said it has .275 in the thrust and that was good. I can't afford an R3 block yet, but I want to build a stroker using a 4.250 crank. So, my question is Can a factory 340 handle a big stroke using 2 bolt mains? Engine will see 6k rpm max.

6K? Bah! That's nothin'. I shifted my stock-stroke 340 at 7,200 with 2 bolt mains.