Best magnum MPG?

More weight is more effort and more effort is more fuel consumption. It easy to move an empty wheel barrel around all day compared to one full of dirt. But I'm sure your body will consume more fuel doing it same as your car. Every hundred pounds you drop off your car is something like a gain of 10 hp and an engines hp is directly related to the amount of fuel it burns.
Do you lose .5-1mpg when you bring the family on a road trip compared to driving by yourself? Extra weight, more effort, more fuel consumption- but in practical application it doesn't act that way. I have never personally observed that kind of a change, I've always seen it relatively the same in similar weight brackets despite 100-600 lbs difference.