Mmmmmm.... I just tried 3 SCR calculators with the same number inputs and they all came up within 0.1 point of each other. Most of the variations I have seen have come from entering data incorrectly; the best place to go wrong is to enter the piston valve relief cc's with a + where it should be a - or vice versa. The different pistons manufacturers will list the same valve relief as + or - in their specs, and people don't catch that subtlety; that is the most common place for an error. I've run the numbers on the 318 with the lower pistons multiple times and it always comes out at the same place; at least the Magnum block and head volumes help you quite a bit over the 318 LA. But high 8's is where it ends up for the lower CH pistons.
BTW, if you use the KB's and the Felpro standard head gaskets at .051" thick, then you will right around 9.5 SCR.
As for your goals: 20 mpg in the van is mostly a challenge of moving that big cinder block shape through the air at any speed without killing efficiency. Maybe a chin spoiler? Enginewise with the FI, it seems like an easy goal to get the efficiency; not counting the wind resistance problem you'll face. But I have never cammed or programmed one of those so I'll defer to others on that beyond any general cam experience.
Just a general comment on the cam for fuel efficiency: Higher lift, lower duration and wider LSA. Crane had a series of cams back in the early-mid 70's that they labeled their 'HE' grinds that they came out with in response to the Arab fuel embargo of '73. 'HE' stood for 'hydraulic, efficiency' (I think), and they featured the high lifts, lower durations, and wide LSA's. They did the job and made a wide torque band engine with good economy. So that makes me think you are on the right track with the cams (and is where modern OEM rollers have gone for that reason).
BTW, IMHO, the 350 peak HP WITH the 20 MPG in that van is the compromise you are going to have to fight and make a trade-off. For your broader uses, I'd forego the 350 HP peak number, which you will not use much in reality, and focus on the mileage/torque. That is also partly my personal inclination, but I have built a multi-use engine that towed too and I thought more about torque at lower RPM's and let the peak HP go where it would. That was the engine that used the 192/200 @ .050" cam, and the engine was run almost 100k miles before the forged pistons got to where the blowby was pretty atrocious LOL! You should have better durabiilty with FI and hypers in newer block metallurgy.
With the above said, then certainly don't push the SCR too hard and end up with detonation issues. If you do, you at least have the option to use premium. Keep the knock sensor if the system has one! I don't know enough about the Magnum MPFI to know how it will adapt to detonation. (IMO, Magnummopar would know much better on that.)