MDS, VVT, and transmission options?

Hey Joe, appreciate the pointers! My goal is a 3G hemi powered car with good performance and mid-20's mpg. I'm in the planning stage and my basic question is how to get there: MDS with the required transmission and accessories, and/or VVT, or just a regular auto overdrive transmission? The MDS set-up looks complicated and I wonder whether the juice is worth the squeeze. This is new territory for me - previous projects were small blocks - so I'm grateful for the insights. Thanks, Bill