Plan to hit the road about 5AM... Should put me in Columbus about midnight... Then if I leave at 6 the next morning, I can be at Carlisle around noon. At least that is the plan...
IDK if this helps you estimate drive times, but the run from Columbus to Carlisle is about 5 hours. I used to drive from Cinci to Philly in 8 hrs back when I was still living in both places. Did it every weekend, round trip.
It's about 9 hours from Memphis to Cinci. I did that about 20 times when I moved from Cinci to Memphis.