AEM troubles

Yes it can but his installed tune was a little to aggressive in the timing dept for my combo so I had to change those tables quite a bit. My engine is 7.0L too, 420 cid. My cam is nasty 247/255 @ .050 and has very little vacuum below 1100rpm. You set your AFR targets from idle to 7000rpm and the autotune will then adjust the fuel table accordingly while you drive. Uchoog and I both run MS3 on our Gen III's and he has helped me a bunch and is who led me down the timing road with mine. I like mine with 14 degrees at idle I think he is in the 8-9 area with his, he is at sea level pretty much, I am at around 2300 ft. He has Hilborn with no IAC, I have 92mm TB, stock 6.1 intake and an IAC motor. You will also need to change the base settings for required fuel in tuner studio once you get it hooked up. It needs to know the lb/hr of your injectors and size of engine.