First time Holley tuning help
Definitely want to have your timing up to snuff as mentioned above as this affects vacuum and throttle response a lot.
Power valve plugs open another can of worms with idle mixture and are more suited to tunnel ram appications or very radical cams. How far in do you have to run the idle mixture screws to get it to run decent? If they are just barely cracked open then you definitely need some idle air bypass by using the secondary stop screw or drilling the holes in the primary throttle plates. This allows you to close up the primaries some and cover the transfer slots and stop dumping in fuel at idle. You may also find a PCV valve that has more bypass which can help.