383 build for efficiency

I went and looked at a project car with an original 383. The car was a dud but it got me thinking. As opposed to a magnum or late model hemi swap, could you build a stock bore and stroke 383 for efficiency that would get decent mileage and power, and be reliable for long trips? The goal would be a cruiser that could run A/C and maybe an overdrive. How would you build it? I am thinking Edelbrock or 440 Source heads, FiTech fuel injection, Performer RPM intake, Schumacher headers, maybe a small hydraulic roller cam. Any thoughts?