225 /6 at 250HP?

Well, I'm glad you only half disagree.
I have already built a 360 to go 106 in qtr and to get 32 mpgUS, and with just a 223 cam .
The turbo'd slanty will not be significantly lighter than the NA360.
And the turbo slanty can be set up to make a lot of torque a little off idle, perhaps more than the NA 360 with an 1800TC. So if it hits too hard and goes up in smoke, perhaps a lazier V8 might 60ft better on the street.
I too have put lots of torque through a 7.25. I choose the 8.75 cuz I can slam a different chunk into it in about 75 minutes or less, laying on my back in the hot sun.Everybody has had different experiences with 7.25s, mostly not so good.
I just wanted the OP to hear a bit about the NA side of things.I was purposely vague.
And I left the chassis paragraph until the end as a reminder that money has to be budgeted for these upgrades, regardless of which powerplant the OP chooses,cuz upside down and on fire is not an option, for anybody except maybe JohnForce .