Yup. But turning the mixture screws does not affect the air/fuel ratio. It just adds more or less. If you want to change the ratio, it requires a bleed change or a restricter change.
That's how some many guys end up out in the weeds with a Holley. They start changing bleeds and emulsion and then next thing you know, they start drinking to relax. Then it's a little hippie lettuce with the booze. Next thing you know, they are main lining, all because they got lost with an air bleed correction. See it happen many, many times. It's a sad road.