Cam bearing oil hole alignment

I personally would not worry about that level of misalignment, though it is as far as I would want to go. If you work through all the oil flow restrictions in the oiling path to the heads, this hole's flow area is still >50% larger than the area of the smallest restriction in the oil flow path into the rockers, which is where the rocker hold-down bole goes through the oil passage hole in the bottom of the rocker shaft. I'd expect maybe a few percent reduction in flow, if any.