How much gain with lower gears?

You will see several tenths shaved(as much as 4 tenths possible) if you choose the 3.73's over the 3.23. A 408 will like them.They are quite street friendly and not too bad on the open road with speeds under 65.Several of my PA friends run them in their street cars.They are from south western part of the state with lots of hills and twist and turn roads.Not many places to top out the speedo so tighter gears work well in that area.Gettysburg is a bit hilly if I remember.Not as flat as the south eastern part of the state. Out here I have open long stretches of flat land. 2.76 feel like 4.10's with no overdrive.
Many years ago I ran 3.91's in Plymouth and 4.10's in a hot rod I had. Certainly wouldn't want to road trip any long distance with them but If I could gain more than a couple tenths I may install something lower. I just keep thinking about that possible long road trip I might do with it and dread that low gear. Of coarse someone will soon mention an overdrive transmission but I really just want to stick with my simple "old school" setup.