Is vacuum advance needed with MSD box with a daily driver?

If you don't run vacuum advance but intend to do any road trips you will literally be dumping unburned gas out the tailpipes the entire way, diluting your oil, and raising your exhaust temps for no reason. It will "run fine without it" but 10,000 miles down the road your engine will be more worn than if you had vac advance. Your call, for some people that stuff isn't important.