I would explain this a different way. You degree the cam with the piston at TDC. WHEN you degree the cam on the no1 lobes, this will NORMALLY put the sprocket timing marks at 12 O'clock and 12 O'clock which is normal. The sprocket marks are normally "matched" with no6 "ready to fire" (compression stroke)
Once the cam is IN TIME or DEGREED IN with no1 TDC, then there IS NO "out of sync."
It simply "is" the way it works.........One stroke, with both no1 and no6 "up" to TDC, no1 fires, and the next rotation, no6 fires. BOTH THESE happen with the balancer mark "up" at TDC (negating timing advance) AT THE TIME this is happening, on one firing (no 6) the cam sprocket marks will be matched, and at the other firing (no1) the top sprocket will be at 12 O' clock
This is very true except in one case: You MAY have a mismatch balancer and timing cover. I BELIEVE some of the motor home balancers used a different mark / setup. If you can verify that "all the parts" meaning the timing marker, front cover, and balancer came from the same source, and THEN it is off then yes.....garbage can the balancer
..............The above is an example of why this software sucks