Thinking about 4.10's

No, none at all.
Well, maybe excessive tire smoke issues. This may cause a lighter weight wallet.
There's also the real possibility of doctor visits because of pain in the jaw/face from prolong smiling.
Do be notified that your local police department may have you pay an extra happiness tax for speeding. I know that one allways sucked to donate to. But it happens.

Remember to get a new speedometer gear for the larger tires based on a 1:1 ratio with the 4.10 gears.