There is no HP "gain" to reversing piston offset, but the actual effects are very noticeable.
By reversing the offset, you are leaning the rod into the direction of crankshaft rotation earlier in the cycle giving peak cylinder pressure a bit more leverage to work the reciprocating assembly.
The engine will feel snappier and hit the converter harder.
I have done this on all of my own engines (when possible) over the last 40 years and can tell you first hand the back to back difference is profound