Exactly!
I’ve got an innovate LC2 in my Duster. You can absolutely drive yourself nuts. The Holley 750 DP I run is pretty temperature sensitive, I go up and down on the primaries for summer and winter. And in the spring and fall I usually leave the winter setting in place so it starts better cold.
That said, I agree with trailbeast. You’re pretty close already, you can probably drop a size on the primaries to get better mileage at cruise. Your accelerator pump may be too big or too sensitive, the carb type will change how you deal with that. On a Holley I’d look at the pump cam and nozzle. A pump cam with a slower ramp may help, or just a downsize on the nozzle. But that’s for a Holley.