Living with a 2.21....
I had a 1988 Fifth Avenue for a while, I swapped the rear end for an 8-1/4" out of a Jeep Cherokee XJ (direct fit, all it needs is the spring hangers flipped and moved and the shock mounts cut off) with 3.07 gears (open of course), that made a HUGE difference in the acceleration with that mod alone and it would still cruise at 3000 RPM at 80 MPH (typical freeway speed around here). At the time the engine did have homemade 2-1/4" duals but still the stock 2-bbl Holley with the Lean-Burn system and the difference was obvious; once I converted to 4-bbl that thing really screamed compared to when it was bone stock. The guy I sold it to lives about a half-hour from me and we're friends on FB so I see his updates on the car; he's either going to rebuild the 318 or swap in a hot 360 and most likely do an O/D trans although I don't think he understands how much work that is lol.
Oh yeah and it was getting around 18 MPG mixed 60/40 hwy/city with an old semi-worn-out ThermoQuad, the current owner put on a brand-new 600 cfm Edelbrock and claims he's getting 20 now. I'm sure it would be higher with taller gears since where he lives is mostly open country roads but he and I both like the acceleration the way it is.