72 Dart Swinger 3.6L Pentastar +T5

The north/south oriented 3.6L Pentastar and auto trans setup in the 2015 Grand Cherokee RWD is canted 8° off horizontal toward the rear.

If this same package was subsequently installed in a project vehicle, such as the Swinger, perfectly level at 0°, would there be any future operational consequences ?

Back in the 1980s GM had an east/west FWD Buick V6 engine, that was no doubt installed horizontally across the frame. That same engine apparently without changes but with different trans was then also used by the GM Australian Holden Comodore, in a north/south RWD config. and they had it tilted backwards (I don't know the angle). Apparently as a result, GM initially experienced numerous problems with the engine in the Holden cars, and I'm told major cylinder head hot-spot problems.

Of course, vehicles are designed to go up hill and down dale from time to time, but I guess primarily designed to run on the flat for extended periods at high speed.

Any thoughts ?