Upgrading to 3/8 fuel line

I will stay with the 5/16" fuel line. A Hemi or dual quad big block may need a 3/8" line but probably not a 360. Would the existing vapor vent system work well enough to allow fuel to flow to the fuel pump and adjust for expansion in the fuel tank if I just cover the end of the vapor line (that originally went to the s6 breather cap) with screen to allow air movement in that line? Thanks for your replies.

You could. Leave the line HIGH to prevent siphon. Another thing you could do is tee it into the breather to the filter bonnet. Will help keep fumes at bay